http://dx.doi.org/10.31703/grr.2021(VI-I).12
10.31703/grr.2021(VI-I).12
Published : Mar 2021
A Study of Awareness and Knowledge about Epidermodysplasia Verruciformis-A Genetic Disorder
Tree man syndrome is a rare inherited skin disorder, including persistent infection caused by human papillomavirus, as a result of which a defect in cell-mediated immunity takes place. This infection results in the growth of scaly macules and papules, mostly on the feet and hands. It is a lifelong disorder that can be treated in surgical and nonsurgical ways. A questionnaire or awareness-based study was conducted among the population of Karachi, Pakistan (both medical and non-medical). It was attended by 506 individuals. To raise the consciousness of this illness. The questions evaluated their knowledge of tree man illness, the possible consequences of the condition and the latest therapies. More than 80% of people were totally unaware of tree man disorder. Only 10% of people were aware or just heard about this disease. The awareness of Tree man syndrome was very low among the people. Steps should be taken to increase awareness about this rare but life-threatening disease.
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Tree Man Syndrome, Lewandowsky-Lutz, Awareness
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(1) Tania Naveel
MPHIL Scholar, Department of Pharmacology, Jinnah University for Women, Karachi, Sindh, Pakistan.
(2) Sidra Afzal
PHD Scholar, HITEC-IMS Medical College, Taxila Cantonment, Punjab, Pakistan.
(3) Mahira Afzal
Communication Officer, United Nations World (WFP), Pakistan.
- Androphy, EJ. Dvoretzky, I. Lowy, DR. (1985). Xlinked inheritance of epidermodysplasia verruciformis. Genetic and virologic studies of a kindred. Arch Dermatol. 121(7):864-868.
- Cougoul, P., et al.,(2015). Acquired epidermodysplasia verruciformis, a new opportunistic infection related to bendamustine. Annals of hematology, 94(6): p. 1071-1073.
- De Jong, S.J., et al., (2018b) The human CIB1- EVER1-EVER2 complex governs keratinocyteintrinsic immunity to β-papillomavirusesCIB1 deficiency in epidermodysplasia verruciformis. The Journal of experimental medicine, 215(9): p. 2289-2310.
- De Jong, S.J., et al.,(2018a). Epidermodysplasia verruciformis: inborn errors of immunity to human beta-papillomaviruses. Frontiers in microbiology, 9: p. 1222.
- De Oliveira, W.R., et al., (2015). Deleterious effect of radiation therapy on epidermodysplasia verruciformis patients. Journal of Cutaneous Medicine and Surgery,19(4): p. 416-421.
- Genetics. 32(4):579-81.doi:10.1038/ng1044. PMID 12426567. https://doi. org/10.1038/ng1044.
- Gül, Ü., et al., (2007). Clinical aspects of epidermodysplasia verruciformis and review of the literature. International journal of dermatology, 46(10): p. 1069-1072.
- Hague, J.E., & Crosby, E.L. (1948). Television Newest Aid in Teaching Surgery, Mod Hosp 70:65-67 (April).
- Harris, J.J. (1966). Television as an Educational Medium in Medicine: An Historical Purview, J Med Educ 41:1-19 (Jan).
- Kim, C., et al., (2016). Treatment of Imiquimod Resistant Epidermodysplasia Verruciformis With Ingenol Mebutate. Journal of drugs in dermatology: JDD, 15(3): p. 350.
- Lazarczyk, M. Pons, C. Mendoza, JA. Cassonnet, P. Jacob, Y. & Favre, M. (2008).
- Lutzner, MA. (1978). Epidermodysplasia verruciformis. An autosomal recessive disease characterized by viral warts and skin cancer. A model for viral oncogenesis. Bull Cancer. 65(2):169-182.
- Myers, D.J. & Fillman, E.P. (2019). Epidermodysplasia verruciformis, in StatPearls [Internet]. 2019, StatPearls Publishing
- Orth, G. (1986). Epidermodysplasia verruciformis: a model for understanding the oncogenicity of human papillomaviruses. Ciba Found Symp. 120:157-174.
- Przybyszewska, J., A. Zlotogorski, & Y. Ramot, (2017). Re-evaluation of epidermodysplasia verruciformis: reconciling more than 90 years of debate. Journal of the American Academy of Dermatology, 76(6): p. 1161-1175.
- Ramoz, N. Rueda, LA. Bouadjar, B. Montoya, LS. Orth, G. & Favre M. (2002).
- Sehgal VN, Luthra A, Bajaj P. (2002). Epidermodysplasia verruciformis: 14 members of a pedigree with an intriguing squamous cell carcinoma transformation. Int J Dermatol. 41(8):500-503.
- Sun, XK. Chen, JF. & Xu, AE. (2005). A homozygous nonsense mutation in the EVER2 gene leads to epidermodysplasia verruciformis. Clin Exp Dermatol. 30(5):573-
- Zavattaro, E. Azzimonti, B. Mondini, M. et al. (2008). Identification of defective Fas function and variation of the perforin gene in an epidermodysplasia verruciformis patient lacking EVER1 and EVER2 mutations. J Invest Dermatol. 128 (3):732- 5.
Cite this article
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APA : Naveel, T., Afzal, S., & Afzal, M. (2021). A Study of Awareness and Knowledge about Epidermodysplasia Verruciformis-A Genetic Disorder. Global Regional Review, VI(I), 105-111. https://doi.org/10.31703/grr.2021(VI-I).12
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CHICAGO : Naveel, Tania, Sidra Afzal, and Mahira Afzal. 2021. "A Study of Awareness and Knowledge about Epidermodysplasia Verruciformis-A Genetic Disorder." Global Regional Review, VI (I): 105-111 doi: 10.31703/grr.2021(VI-I).12
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HARVARD : NAVEEL, T., AFZAL, S. & AFZAL, M. 2021. A Study of Awareness and Knowledge about Epidermodysplasia Verruciformis-A Genetic Disorder. Global Regional Review, VI, 105-111.
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MHRA : Naveel, Tania, Sidra Afzal, and Mahira Afzal. 2021. "A Study of Awareness and Knowledge about Epidermodysplasia Verruciformis-A Genetic Disorder." Global Regional Review, VI: 105-111
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MLA : Naveel, Tania, Sidra Afzal, and Mahira Afzal. "A Study of Awareness and Knowledge about Epidermodysplasia Verruciformis-A Genetic Disorder." Global Regional Review, VI.I (2021): 105-111 Print.
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OXFORD : Naveel, Tania, Afzal, Sidra, and Afzal, Mahira (2021), "A Study of Awareness and Knowledge about Epidermodysplasia Verruciformis-A Genetic Disorder", Global Regional Review, VI (I), 105-111
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TURABIAN : Naveel, Tania, Sidra Afzal, and Mahira Afzal. "A Study of Awareness and Knowledge about Epidermodysplasia Verruciformis-A Genetic Disorder." Global Regional Review VI, no. I (2021): 105-111. https://doi.org/10.31703/grr.2021(VI-I).12